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Portland is the largest and most populous city in the U.S. state of Oregon and the seat of Multnomah County. It is a major port in the Willamette Valley region of the Pacific Northwest, at the confluence of the Willamette and Columbia rivers. As of 2018, Portland had an estimated population of 653,115, making it the 25th most populated city in the United States, and the second-most populous in the Pacific Northwest (after Seattle). Approximately 2.4 million people live in the Portland metropolitan statistical area (MSA), making it the 25th most populous in the United States. Its Combined Statistical Area (CSA) ranks 19th-largest with a population of around 3.2 million.