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Appleseed takes place in the 22nd century, after the non-nuclear Third World War has led to the destruction of a majority of the Earth's people. While countries like Great Britain, USA and China have difficulty maintaining order and power, international organizations like the "Sacred Republic of Munma" and "Poseidon" have been established in the aftermath. The main characters are Deunan Knute and Briareos Hecatonchires, former SWAT members of the LAPD. They are found in the desolated city and invited to join the prestigious ESWAT (Extra Special Weapons And Tactics) organization in the utopian city of Olympus, the new world's most powerful state. The series follows Deunan and Briareos as they protect their new home.